The SCCNFP is aware of a number of reports in the scientific literature of para-phenylenediamine (PPD), and probably similar substances, having caused severe allergic contact dermatitis when used as ingredients in so-called temporary tattoos (skin stains).
PPD and similar chemicals have been assessed by the SCCNFP for use as hair colouring agents. Appropriate recommendations on use concentrations, restrictions and warnings for such application are in the EC Cosmetics Directive.
When PPD and similar chemicals are used for skin staining (temporary tattoos), active sensitisation may occur within a few weeks and the reactions can be very severe. Pigmentary variegation may persist for a prolonged period following such reactions. The sensitisation will be life long.
Following active sensitisation there may be extensive cross reactivity to other commonly encountered chemical substances to which the consumer may be exposed. These include other hair colouring agents, textile dyes, drugs and rubber chemicals.
The SCCNFP is of the opinion that PPD and similar chemicals should not be used in skin stains (temporary tattoos).