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Public Health
Expert opinion

2,5,6-Triamino-4-pyrimidinol sulfate (A143)

Final Opinion


Publication date
25 June 2015
Scientific Committee on Consumer Safety (SCCS)


WG on Hair dyes
SCCS members:Q. Chaudhry, P.J. Coenraads, M. Dusinska, W. Lilienblum, E. Nielsen, T. Platzek, S. C. Rastogi, Ch. Rousselle, J. van Benthem
External experts: A. Bernard, L. Bodin, J. Duus-Johansen, J. Ezendam, A. Giménez-Arnau, E. Mirkova, E. Panteri, T. Vanhaecke
On request from: European Commission
SCCS Number: SCCS/1561/15
Adopted on: 25 June 2015

Conclusion of the opinion:

(1) In light of the new data provided, does SCCS consider 2,5,6-Triamino-4-pyrimidinol sulfate as safe for use as an oxidative hair with an on-head concentration of 0.5%?

In the light of the new data provided, the SCCS considers the use of 2,5,6-triamino-4-pyrimidinol sulfate as an ingredient in oxidative hair dye formulations at a maximum concentration of 0.5% on the head is safe.

(2) Does the SCCS have any further scientific concerns with regard to the use of 2,5,6-Triamino-4-pyrimidinol sulfate in cosmetic products?

A skin sensitising potential of 2,5,6-triamino-4-pyrimidinol sulfate cannot be excluded.


SCCS, scientific opinion, 2,5,6-Triamino-4-pyrimidinol sulphate, A143, Regulation 1223/2009, CAS 1603-02-7, EC

Opinion to be cited as:

SCCS (Scientific Committee on Consumer Safety), Opinion on 2,5,6-Triamino-4-pyrimidinol sulphate (A143), 25 June 2015, SCCS/1561/15.


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