3-Benzilydene camphor (S61)

WG on Cosmetic Ingredients
SCCS members: U. Bernauer, P.J. Coenraads, G. Degen, D. Gawkrodger, W. Lilienblum, A. Luch, E. Nielsen, T. Platzek, S.C. Rastogi (chairman), C. Rousselle(rapporteur), J. van Benthem
External experts: V. Rogiers, I.R. White
Contact:SANTE-C2-SCCSec [dot] europa [dot] eu (SANTE-C2-SCCS[at]ec[dot]europa[dot]eu)
On request from: European Commission
SCCS Number: SCCS/1513/13
Doi: 10.2772/67725
Adopted on: 18 June 2013

Conclusion of the opinion:

Due to MoS < 100, the SCCS considers that the use of 3-benzylidene-camphor as a UV-filter in cosmetic products in a concentration up 2.0% is not safe. Concerning the potential endocrine disruptor properties of 3-BC, multiple hormonal activities of 3-BC have been reported in vitro: estrogenic and anti-estrogenic effects as well anti androgenic activities. In vivo, the expression of target genes (ERα, ERβ, SRC-1 and PR (progesterone receptor)) has been shown to be altered in both males and females rats at doses lower than the NOAEL used to calculate the MoS. Due to some shortcomings in the studies, the results need to be confirmed.

Keywords:

SCCS, scientific opinion, UV-filter, S61, 3-benzylidene camphor, directive 76/768/ECC

Opinion to be cited as:

SCCS (Scientific Committee on Consumer Safety), Opinion on 3- benzylidene camphor, 18 June 2013.