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Public Health
Expert opinion

Trimethylbenzoyl diphenylphosphine oxide (TPO)

Final Opinion


Publication date
27 March 2014
Scientific Committee on Consumer Safety (SCCS)


WG on Cosmetic Ingredients
SCCS members: U. Bernauer, P.J. Coenraads, G. Degen, M. Dusinska, D. Gawkrodger, W. Lilienblum (rapporteur), A. Luch, E. Nielsen, T. Platzek, S.C. Rastogi (chairman), C. Rousselle, J. van Benthem
External experts: V. Rogiers, T. Sanner, I.R. White
On request from: European Commission
SCCS Number: SCCS/1528/14
Doi: 10.2772/45370
Adopted on: 27 March 2014

Conclusion of the opinion:

The SCCS is of the opinion that Trimethylbenzoyl diphenylphosphine oxide (TPO) is safe when used as a nail modelling product at a concentration of at maximum 5.0%. However, TPO is considered a moderate skin sensitizer. Other potential uses of Trimethylbenzoyl diphenylphosphine oxide in cosmetic products cannot be evaluated without further documentation.


SCCS, scientific opinion, cosmetic ingredients, Trimethylbenzoyl diphenylphosphine oxide (TPO), Regulation 1223/2009, CAS 75980-60-8 , EC 278-355-8

Opinion to be cited as:

SCCS (Scientific Committee on Consumer Safety), Opinion on the safety of Trimethylbenzoyl diphenylphosphine oxide (TPO) in cosmetic products, submission I, 27 March 2014, SCCS/1528/14.


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