2-Chloro-p-phenylenediamine (A8)

WG on Hair Dyes
SCCS members:M. Dusinska, D. Gawkrodger, W. Lilienblum, M. Metzler, E. Nielsen, T. Platzek (chairman), S.C. Rastogi, C. Rousselle, J. van Benthem
External experts:M. Pilar Vinardell, I. White (rapporteur)
Contact:SANTE-C2-SCCSec [dot] europa [dot] eu (SANTE-C2-SCCS[at]ec[dot]europa[dot]eu)
On request from: European Commission
SCCS Number: SCCS/1510/13
Doi: 10.2772/71296
Adopted on: 19 September 2013

Conclusion of the opinion:

The SCCS considers that no sufficient margin of safety could be deduced for the use of 2-chloro-p-phenylenediamine in oxidative hair dye formulations for eyebrows and eyelashes in a concentration of maximum 4.6 % taking into account the scientific data provided. 2-Chloro-p-phenylenediamine is categorised as at least a ‘strong’ sensitiser. A complete chemical characterisation of 2-chloro-p-phenylenediamine is needed. The SCCS is of the opinion, that based on the available data and the lack of a proper in vivo test for gene mutation induction, it is not possible to give a conclusion on the genotoxic potential of 2-chloro-p-phenylenediamine. Therefore, the use of 2-chloro-p-phenylenediamine cannot be considered safe for the consumer.

Keywords:

SCCS, scientific opinion, hair dye, A8, 2-Chloro-p-phenylenediamine, directive 76/768/ECC, CAS: 615-66-7 (free base), EC: 210-441-2

Opinion to be cited as:

SCCS (Scientific Committee on Consumer Safety), Opinion on 2-Chloro-p-phenylenediamine, 19 September 2013.