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Public Health
Expert opinion

Fragrance ingredient Acetylated Vetiver Oil (AVO) - submission III

Final Opinion


Publication date
26 February 2019
Scientific Committee on Consumer Safety (SCCS)


WG on Cosmetic Ingredients
SCCS members: U. Bernauer, L. Bodin, Q. Chaudhry, P.J. Coenraads (Chairperson), M. Dusinska, J. Ezendam, E. Gaffet, C. L. Galli (Rapporteur), B. Granum, E. Panteri, V. Rogiers, Ch. Rousselle, M. Stepnik, T. Vanhaecke, S. Wijnhoven
SCCS external experts: A. Simonnard, A. Koutsodimou
Contact: SANTE-C2-SCCSatec [dot] europa [dot] eu (SANTE-C2-SCCS[at]ec[dot]europa[dot]eu)
On request from: European Commission
SCCS Number: SCCS/1599/18
Adopted on: 26 February 2019

Conclusion of the opinion:

1. On the basis of currently available information, does the SCCS consider Acetylated Vetiver Oil (AVO) safe for use as fragrance ingredient in cosmetic leave-on and rinse-off type products in a concentration limit(s) according to the once set up by IFRA as reported above?

On the basis of the safety assessment carried out using a conservative approach, the SCCS considers the use of Acetylated Vetiver Oil (AVO) with 1% alpha-tocopherol as a fragrance ingredient in cosmetic leave-on and rinse-off type products safe at the concentrations proposed by IFRA.

2. Does the SCCS have any further scientific concerns with regard to the use of Acetylated Vetiver Oil (AVO) as fragrance ingredient in cosmetic leave-on and rinse-off type products?

Acetylated Vetiver Oil (AVO) contains some constituents that belong to the chemical group of aldehydes and ketones that are known to be reactive towards biological entities, such as DNA and proteins. However, the overall health risk of such components is likely to be negligible at the concentrations intended to be used in cosmetics products.

The SCCS has noted that Acetylated Vetiver Oil (AVO) is a moderate skin sensitiser in test animals. Considering the results of the HRIPT study and the fact that AVO has been used for years in cosmetics without evidence of sensitising potential, it is unlikely that AVO would be causing contact allergy in humans.

Inhalation toxicity of Acetylated Vetiver Oil (AVO) was not assessed in this Opinion because no data were provided. Assessment of the inhalation risk would be needed if AVO was intended to be used in sprayable products.


SCCS, scientific opinion, Acetylated Vetiver Oil (AVO), Regulation 1223/2009, Vetiverol acetate CAS 62563-80-8; Vetiveria zizanioides ext. acetylated, CAS 84082-84-8, EC 282-031-1, SCCS/1599/18

Opinion to be cited as:

SCCS (Scientific Committee on Consumer Safety), Opinion on fragrance ingredient Acetylated Vetiver Oil (AVO) - Submission III, SCCS/1599/18, preliminary version of 21-22 June 2018, final version of 26 February 2019, CORRIGENDUM on 20-21 June 2019.