Hydroxypropyl p-phenylenediamine and its dihydrochloride salt (A165)

WG on Cosmetic Ingredients
SCCS members: U. Bernauer, L. Bodin, Q. Chaudhry, P.J. Coenraads (Chairperson), M. Dusinska, J. Ezendam (Rapporteur), E. Gaffet, C. L. Galli, B. Granum, E. Panteri, V. Rogiers, Ch. Rousselle, M. Stepnik, T. Vanhaecke, S. Wijnhoven
SCCS external experts: A. Koutsodimou, A. Simonnard, W. Uter
Contact: SANTE-C2-SCCSec [dot] europa [dot] eu (SANTE-C2-SCCS[at]ec[dot]europa[dot]eu)
On request from: European Commission
SCCS Number: SCCS/1608/19
Adopted on: 30-11 October 2019

Conclusion of the opinion:

In light of the data provided, does the SCCS consider Hydroxypropyl p-phenylenediamine and its dihydrochloride salt (A165), safe when used in oxidative hair colouring products up to a maximum on-head concentration of 2 %?

In light of the data provided, the SCCS considers that hydroxypropyl p-phenylenediamine and its dihydrochloride salt are not safe when used in oxidative hair colouring products due to potential genotoxicity.

2. Does the SCCS have any further scientific concerns with regard to the use of Hydroxypropyl p-phenylenediamine and its dihydrochloride salt (A165) in cosmetic products?

A mild to moderate eye irritation potential of the test item cannot be excluded. Hydroxypropyl p-phenylenediamine 2HCl is a moderate skin sensitiser based on animal data.

Keywords:

SCCS, scientific opinion, Hydroxypropyl p-phenylenediamine and its dihydrochloride salt (A165), Regulation 1223/2009, CAS base 73793-79-0 and salt 1928659-47-5, SCCS/1608/19

Opinion to be cited as:

SCCS (Scientific Committee on Consumer Safety), Opinion on Hydroxypropyl p-phenylenediamine and its dihydrochloride salt (A165), preliminary version of 20-21 June 2019, final version of 30-31 October 2019, SCCS/1608/19.