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Public Health
Expert opinion

Memorandum on Endocrine Disruptors



Publication date
28 January 2015
Scientific Committee on Consumer Safety (SCCS)


SCCS members: U. Bernauer, Q. Chaudhry, P.-J. Coenraads, G. Degen, M. Dusinska, W. Lilienblum, A. Luch, E. Nielsen, T. Platzek, S. Ch. Rastogi, Ch. Rousselle, J. van Benthem
On request from: European Commission
SCCS Number: SCCS/1544/14
Doi: 10.2772/52077
Adopted on: 16 December 2014


Conclusion of the opinion:

Due to the ban on animal testing for cosmetic ingredients effective since 2013, it will be extremely difficult in the future to differentiate between a potential ED and an ED, if the substance is registered solely for use in cosmetic products [Factsheet ECHA-14-FS-04- EN,…]. Yet, for substances registered under REACH and also for other (mixed) uses, crucial information from animal tests is necessary for the time being.

The replacement of animal test methods by alternative methods in relation to complex toxicological endpoints remains scientifically difficult, despite the additional efforts launched at various levels [SCCS/1294/10, Adler et al. 2011, JRC 2014]. With regard to substances with endocrine activity (potential endocrine disruptor), the assessment of their impact to human health without animal data remains a challenge.


SCCS, memorandum, endocrine disruptor, EC Regulation 1223/2009

Opinion to be cited as:

SCCS (Scientific Committee on Consumer Safety), memorandum on Endocrine Disruptors, SCCS/1544/14, 16 December 2014.


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