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Public Health
Expert opinion

Memorandum on the use of In Silico Methods for Assessment of Chemical Hazards


Publication date
6 October 2016
Scientific Committee on Consumer Safety (SCCS)


SCCS members: U. Bernauer, L. Bodin, L. Celleno, Q. Chaudhry, P. Coenraads, M. Dusinska, J. Duus-Johansen, J. Ezendam, E. Gaffet, C. L. Galli, B. Granum, E. Panteri, V. Rogiers, Ch. Rousselle, M. Stepnik, T. Vanhaecke, S. Wijnhoven
Contact:SANTE-C2-SCCSatec [dot] europa [dot] eu (SANTE-C2-SCCS[at]ec[dot]europa[dot]eu)
On request from: European Commission
SCCS Number: SCCS/1578/16
Adopted on: 6 October 2016


The European Commission’s Independent Scientific Committee on Consumer Safety (SCCS) provides scientific opinions on health and safety risks of non-food consumer products (e.g. cosmetic products and their ingredients, toys, textiles, clothing, personal care and household products) and services (e.g. tattooing, artificial sun tanning).
Testing cosmetic ingredients and products on animals, and marketing of new cosmetic ingredients/products tested on animals, is now banned in Europe under the EU Cosmetics Regulation (Regulation (EC) No 1223/2009). This has brought the focus on alternative non-animal methods to derive safety data for cosmetic ingredients. The alternative methods include in silico (computational) models and systems that are based on (quantitative) structure-activity relationship, and/or read-across between structurally/functionally similar substances. This Memorandum is intended to provide a general perspective on the current status of in silico methods in risk assessment of cosmetic ingredients in Europe.


SCCS, Memorandum, use of In silico Methods, Assessment of Chemical Hazard, Regulation 1223/2009

Opinion to be cited as:

SCCS (Scientific Committee on Consumer Safety), Memorandum on the use of In silico Methods for Assessment of Chemical Hazard, 6 October 2016, SCCS/1578/16.


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