SCCS - Opinion on Ethylhexyl Methoxycinnamate (EHMC) (CAS No. 5466-77-3/83834-59-7, EC No. 226-775-7/629-661-9)

SCCS members: U. Bernauer, L. Bodin, Q. Chaudhry, P.J. Coenraads (Chairperson), J. Ezendam, E. Gaffet, C. L. Galli, E. Panteri, V. Rogiers, Ch. Rousselle (Rapporteur), M. Stepnik, T. Vanhaecke, S. Wijnhoven
SCCS external experts: E. Benfentati, N. Cabaton (Rapporteur), E. Corsini, A. Koutsodimou, H. Louro , W. Uter, N. von Goetz
Contact: SANTE-SCCS@ec.europa.eu
On request from: European Commission
SCCS Number: SCCS/1671/24
Adopted on: 25 October 2024

Conclusion of the opinion:

(1) In light of the data provided and taking under consideration the concerns related to potential endocrine disrupting properties of Ethylhexyl Methoxycinnamate, does the SCCS consider Ethylhexyl Methoxycinnamate safe when used as UV-Filter in cosmetic products up to a maximum concentration of 10%?

Having considered the data provided, and the concerns relating to potential endocrine disrupting properties of EHMC, the SCCS cannot conclude on the safety of EHMC, because the information provided is insufficient to exclude genotoxicity.

In addition, the available evidence also shows that EHMC is an endocrine-active substance due to clear demonstration of estrogenic activity and weak anti-androgenic activity both in vitro and in vivo.

(2) Alternatively, what is according to the SCCS the maximum concentration considered safe for use of Ethylhexyl Methoxycinnamate in cosmetic products?

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(3) Does the SCCS have any further scientific concerns with regard to the use of Ethylhexyl Methoxycinnamate in cosmetic products?

The SCCS mandate does not address environmental aspects. Therefore, this assessment did not cover the safety of EHMC for the environment.

Keywords:

SCCS, scientific opinion, Ethylhexyl Methoxycinnamate (EHMC), Octylmethoxycinnamate (OMC), Octinoxate, Regulation 1223/2009, CAS No. 5466-77-3/83834-59-7, EC No. 226-775-7/629-661-9.

Opinion to be cited as:

SCCS (Scientific Committee on Consumer Safety), Opinion on Ethylhexyl Methoxycinnamate (EHMC) (CAS No. 5466-77-3/83834-59-7, EC No. 226-775-7/629-661-9), preliminary version of 25 October 2024, SCCS/1671/24.